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Distinction of α- and β-aspartyl and α- and γ-glutamyl peptides by fast atom bombardment/tandem mass spectrometry

✍ Scribed by J. R. Lloyd; M. L. Cotter; D. Ohori; D. L. Doyle

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
290 KB
Volume
15
Category
Article
ISSN
1076-5174

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✦ Synopsis

A fast atom bombardment/collisional activation/linked-scan at constant B/E (tandem mass spectrometric) method is described which can distinguish between a-and basparty1 and a-and y-glutamyl underivatized peptides. The method is based upon differences in loss of CO from aspartyl or glutamyl B-fragment ions (I,) in these isomers which are rationalized from the stability of the resultant A-fragment ions (I,). It was observed that the ratio of I, :I, which was used in this determination was dependent upon the collision cell pressure. The higher the collision cell pressure, the larger the difference between the I, : I, ratios for these linkages.

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