Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice
✍ Scribed by Olaf Schulte-Herbrüggen; Heide Hörtnagl; Gerald Ponath; Matthias Rothermundt; Rainer Hellweg
- Book ID
- 116770652
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 135 KB
- Volume
- 442
- Category
- Article
- ISSN
- 0304-3940
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Several studies have suggested a close interaction between serotonin (5-HT) and BDNF; however, little is known of the specific relationship between BDNF and the 5-HT 2C receptor. Therefore, in this study we investigated BDNF expression in 5-HT 2C receptor knockout mice (5-HT 2C KO). We also assessed
## Abstract Neurotrophins play essential roles in the development, differentiation, and survival of neuronal and nonneuronal cells. Alterations in neurotrophin expression have been implicated in a variety of neurodegenerative disorders. Dysregulation of brain‐derived neurotrophic factor (BDNF) has