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Distinct region of the granulocyte colony-stimulating factor receptor mediates proliferative signaling through activation of Janus kinase 2 and p44/42 mitogen-activated protein kinase

✍ Scribed by Debbie C. Koay; Tri-Hung Nguyen; Alan C. Sartorelli


Book ID
114283635
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
255 KB
Volume
14
Category
Article
ISSN
0898-6568

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## Abstract Results presented in this study indicate that in human embryonic kidney 293 cells (HEK 293), the ghrelin receptor growth hormone secretagogue receptor type 1a (GHS‐R1a) activates the extracellular signal‐related kinases 1 and 2 (ERK 1/2) via three pathways. One pathway is mediated by th