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Distinct pathways regulate transforming growth factor β1-stimulated proto-oncogene and extracellular matrix gene expression

✍ Scribed by Philip H. Howe; Muriel R. Cunningham; Edward B. Leof

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
707 KB
Volume
142
Category
Article
ISSN
0021-9541

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✦ Synopsis

The effect of pertussis toxin (PT) on transforming growth factor p l (TGF(S1)induced proto-oncogene expression was investigated in AKR-26 fibroblasts. P 1 substantially abolished c-sis and c-myc mKNA expression following TGFPl stiniulation. This inhibitory effect was specific for TCFf3l -stimulated proto-oncogene expression and associated with the ADP-ribosylation of a 41 -kDa substrate. Actinomycin D decay and nuclear run-on experiments demonstrated that the inhibitory effects of PT are a result of decreased transcriptional activation and not to an increased decay of proto-oncogene message. PT did not, however, affect TGFPlstitnulated fibroncctin and collagen mKNA accumulation nor did it have any inhibitory effect on TGFPl -induced morphological transformation. These data indicate that TGFPl -stimulated gene expression is coupled to multiple pathways distinguished by their sensitivity to PT.

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