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Distinct in vivo CD8 and CD4 T cell responses against normal and malignant tissues

✍ Scribed by David Coe, Caroline Addey, Matthew White, Nida Harwood, Julian Dyson, Jian-Guo Chai

Book ID
118781420
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
760 KB
Volume
62
Category
Article
ISSN
0340-7004

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## Abstract 4‐1BBL^–/–^ mice have a defect in recall CD8^+^ T cell responses to viruses, whereas CD4^+^ T cell responses to virus are unimpaired in these mice. In contrast, both CD4^+^ and CD8^+^ T cells respond to 4‐1BB ligand (4‐1BBL) __in vitro__. To clarify the role of 4‐1BB/4‐1BBL in CD4^+^ ve