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Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab

โœ Scribed by Sebejova, Ludmila; Borsky, Marek; Jaskova, Zuzana; Potesil, David; Navrkalova, Veronika; Malcikova, Jitka; Sramek, Martin; Doubek, Michael; Loja, Tomas; Pospisilova, Sarka; Mayer, Jiri; Trbusek, Martin


Book ID
126758892
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
846 KB
Volume
42
Category
Article
ISSN
0301-472X

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## Abstract The spectrum and pattern of __p53__ mutations detected in 42 cases of Bโ€cell chronic lymphocytic leukemia (Bโ€CLL) were analyzed, and several interesting features were noted. Codon 209 in the __p53__ gene may be a new hotโ€spot for __p53__ mutation in Bโ€CLL disease. Four of the 42 (10%) r