Testicular germ-cell tumors (TGCTs) are pluripotent and display protean histology from the germ-cell stage until embryonal and somatic-cell differentiation. These properties make TGCT a fascinating model for studying germ-cell development and gametogenesis. Methylation patterns specific to cell type
Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors
✍ Scribed by Smiraglia, Dominic J; Szymanska, Jadwiga; Kraggerud, Sigrid M; Lothe, Ragnhild A; Peltomäki, Päivi; Plass, Christoph
- Book ID
- 110066679
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 192 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Hypermethylation of tumor‐suppressor genes has been implicated in the pathogenesis of human cancers. Although a growing number of genes showing hypermethylation is being reported in human cancer, methylation profiles of tumor‐related genes in testicular neoplasms have not been well eluc
Background. Hyperpentaploidy in testicular nonseminomatous germ cell tumors (TNSGCT) has been associated with progression of disease of patients who initially had TNSGCT in Stage I. Methods. The authors used flow cytometry to investigate the relationship between ploidy and the clinical behavior in