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Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying

✍ Scribed by Nataša Jovanović; Andréanne Bouchard; Gerard W. Hofland; Geert-Jan Witkamp; Daan J.A. Crommelin; Wim Jiskoot

Book ID
113591592
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
533 KB
Volume
27
Category
Article
ISSN
0928-0987

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The stability of nonviral vectors during freeze-drying has been well-studied, and it has been established that sugars can protect lipoplexes during freeze-drying. However low levels of damage are often observed after freeze-drying, and this damage is more evident in dilute lipoplex preparations. By