✦ LIBER ✦

Distant metastases after definitive radiotherapy for squamous cell carcinoma of the head and neck

✍ Scribed by Majid O. F. Al-Othman; Christopher G. Morris; Russell W. Hinerman; Robert J. Amdur; William M. Mendenhall

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 76 KB
Volume: 25
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.10275

No coin nor oath required. For personal study only.

✦ Synopsis

Purpose:

To analyze parameters that influence the risk of distant metastases after definitive radiotherapy.

Methods:

Between 1983 and 1997, 873 patients were treated with definitive radiotherapy and had follow-up for 2 years or more. univariate and multivariate analyses were performed to evaluate risk factors that might influence the risk of distant metastases.

Results:

The 5-year distant metastasis-free survival rate was 86%. univariate analyses revealed that the risk of distant metastases was significantly influenced by gender (p =.0092), primary site (p =.0023), t stage (p <.0001), n stage (p <.0001), overall stage (p <.0001), level of nodal metastases in the neck (p <.0001), histologic differentiation (p =.0096), control above the clavicles (p <.0001), and time to locoregional recurrence (p <.0001). multivariate analysis of freedom from distant metastases revealed that gender (p =.0390), t stage (p <.0001), n stage (p =.0060), nodal level (p <.0001), and locoregional control (p <.0001) significantly influenced this end point. multivariate analysis revealed that gender (p =.0049), t stage (p <.0001), n stage (p <.0001), and locoregional control (p <.0001) significantly influenced cause-specific survival.

Conclusions:

The risk of distant metastases after definitive radiotherapy is 14% at 5 years and is significantly influenced by gender, t stage, n stage, nodal level, and locoregional control.

📜 SIMILAR VOLUMES

Planned neck dissection after definitive

Planned neck dissection after definitive radiotherapy for squamous cell carcinoma of the head and neck

✍ William M. Mendenhall; Douglas B. Villaret; Robert J. Amdur; Russell W. Hinerman 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB 👁 2 views

## Abstract ## Background. To define the role of planned neck dissection after definitive radiotherapy for patients with node‐positive squamous cell carcinoma of the head and neck. ## Methods. Review of the pertinent literature. ## Results. Radiotherapy alone produces a relatively high likelih

Impact of race on outcome after definiti

Impact of race on outcome after definitive radiotherapy for squamous cell carcinoma of the head and neck

✍ Majid O. F. Al-Othman; Christopher G. Morris; Henrietta L. Logan; Russell W. Hin 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB 👁 1 views

## Background: The objective of the current study was to evaluate the impact of race (black vs. white) on the outcome of patients with invasive squamous cell carcinoma of the head and neck. ## Methods: Between 1983 and 1997, 686 patients completed definitive, twice-daily radiotherapy (rt) alone o

Parameters that predict local control af

Parameters that predict local control after definitive radiotherapy for squamous cell carcinoma of the head and neck

✍ William M. Mendenhall; Christopher G. Morris; Robert J. Amdur; Russell W. Hinerm 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB 👁 2 views

## Abstract ## Purpose. To analyze parameters that may influence the likelihood of local control after definitive radiotherapy for head and neck cancer. ## Methods. Between April 1980 and January 2000, 404 patients were treated with definitive RT alone (358 patients) or combined with adjuvant ch

Radiotherapy for basaloid squamous cell

Radiotherapy for basaloid squamous cell carcinoma of the head and neck

✍ Dr. James M. Larner; Dr. Ronald H. Malcolm; Dr. Stacey E. Mills; Dr. Henry F. Fr 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 451 KB 👁 2 views

Basaloid squamous cell carcinoma (BSCC) of the head and neck is a recently described high-grade variant of squamous cell carcinoma. It is a biologically virulent neoplasm with a propensity for nodal, as well as systemic, metastases. Because of the limited number of published reports, we reviewed dat

Distant metastases in epidermoid cell ca

Distant metastases in epidermoid cell carcinoma of the head and neck

✍ Paul H. O'Brien; Rodney Carlson; Erwin A. Steubner Jr.; Charles T. Staley 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 English ⚖ 260 KB 👁 2 views

The pattern of metastases in patients who died of epidermoid cancer of the head and neck area, between 1954 and 1967, at the Veterans Administration Research Hospital, Chicago, was studied. One hundred fifty-tlwee patients died of epidermoid cancer of the head and neck; metastases below the clavicle

Bone metastases from squamous cell carci

Bone metastases from squamous cell carcinoma of the head and neck

✍ Marc P. Pietropaoli; Timothy A. Damron; Andrei I. Vermont 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB 👁 2 views

Background and Objectives: Carcinoma of the head and neck is an uncommon primary source of bone metastases. The increasing duration of survival of these patients, however, increases the probability of late bone involvement. The objective was to identify the frequency, clinical presentation, and clin