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Dissolution testing of soft shell capsules–Acetaminophen and nifedipine

✍ Scribed by Carey B. Bottom; Marijo Clark; J. T. Carstensen

Book ID
109388650
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
159 KB
Volume
86
Category
Article
ISSN
0022-3549

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Delayed absorption of nifedipine when administered as a 20 mg immediate release soft gelatin capsule to fasted volunteers has been reported. Physiologically based pharmacokinetic (PBPK) modeling and in vitro dissolution data were used to explore our hypothesis that at high doses of nifedipine it pre