Dissolution of Hydrocortisone in Human and Simulated Intestinal Fluids
✍ Scribed by Betty Lomstein Pedersen; Helle Brøndsted; Hans Lennernäs; Finn Norring Christensen; Anette Müllertz; Henning Gjelstrup Kristensen
- Book ID
- 110250999
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 151 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
It was the purpose of this study to explore supersaturation of poorly soluble drugs in human intestinal fluids (HIF), and to assess potential food effects on the creation and maintenance of supersaturation. Duodenal fluids were collected from healthy volunteers and pooled according to three nutritio
Data are presented showing that the anomalous dissolution behavior of ticrynafen in simulated intestinal fluid without enzyme is due to the presence of potassium ions in the dissolution medium. Solubility studies indicate that an insoluble 1:l complex is formed between ticrynafen and its potassium s