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Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids

✍ Scribed by Sarah Clarysse; Joachim Brouwers; Jan Tack; Pieter Annaert; Patrick Augustijns

Book ID
113592463
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
605 KB
Volume
43
Category
Article
ISSN
0928-0987

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It was the purpose of this study to explore supersaturation of poorly soluble drugs in human intestinal fluids (HIF), and to assess potential food effects on the creation and maintenance of supersaturation. Duodenal fluids were collected from healthy volunteers and pooled according to three nutritio