Dissolution kinetics of cholesterol in simulated bile II: Influence of simulated bile composition
โ Scribed by K. H. Kwan; W. I. Higuchi; A. F. Hofmann
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 423 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
Duodenal bile obtained from patients with gallstones who were acutely infused with chenodeoxycholic acid, ursodeoxycholic acid, or cholic acid were examined for the propensity toward the formation of a liquid crystalline mesomorphic phase when cholesterol gallstones were incubated in these bile acid
Many studies have demonstrated that gallbladder bile (but not hepatic bile) of animals or patients with cholesterol gallstones contains higher protein concentrations than does gallbladder bile of control patients without stones or with pigment stones. The underlying defect has not been elucidated. T
Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7a-hydroxylase, the rate-limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile ac