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Dissociation of Mitogenesis and Transforming Activity by C-Terminal Truncation of the Insulin-like Growth Factor-I Receptor

✍ Scribed by Ewa Surmacz; Christian Sell; Jennifer Swantek; Hisanori Kato; Charles T. Roberts Jr.; Derek LeRoith; Renato Baserga


Book ID
115602048
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
773 KB
Volume
218
Category
Article
ISSN
0014-4827

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Insulin-like growth factor I receptor is
✍ Tiziana Deangelis; Andres Ferber; Renato Baserga πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 971 KB

## Abstract R^βˆ’^ cells are 3T3‐like cells derived from mouse embryos in which the insulin‐like growth factor I (IGF‐I) receptor (IGF‐IR) genes have been disrupted by targeted homologous recombination. These cells cannot grow in serum‐free medium supplemented by the growth factors that sustain the g