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Dissociation of Antimicrobial and Hemolytic Activities of Gramicidin S through N - Methylation Modification

โœ Scribed by Li, Yangmei; Bionda, Nina; Yongye, Austin; Geer, Phaedra; Stawikowski, Maciej; Cudic, Predrag; Martinez, Karina; Houghten, Richard A.

Book ID
121686773
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
583 KB
Volume
8
Category
Article
ISSN
1860-7179

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## Abstract Gramicidin S (GS) is a cycloโ€decapeptide antibiotic isolated from __Bacillus brevis__. The structural studies have shown that GS forms a twoโ€stranded antiparallel ฮฒโ€sheet imposed by two IIโ€ฒ ฮฒโ€turns. Despite its wide Gram+ and Gramโˆ’ antimicrobial spectrum, GS is useless in therapy becaus