Chromatographic determination of aqueous
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Oumada, Fadoua Z. (author);Raand̀fols, Clara (author);Roseand́s, Martiand́ (auth
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Article
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2002
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John Wiley and Sons Inc.
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English
⚖ 140 KB
The purpose of this work is to propose a new, useful, and easy chromatographic method to determine accurately the aqueous dissociation constant of drugs sparingly soluble in water. The method uses the rigorous intersolvental pH scale, (w)(s)pH, i.e., the pH measurements are made in the mobile phase