Dissociation between biochemical and behavioral recovery in MPTP-treated mice
โ Scribed by F.B. Weihmuller; M. Hadjiconstantinou; J.P. Bruno
- Book ID
- 113223415
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 446 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0091-3057
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The systemic administration of 1-methyl-4-phenyl-1,2,3,64etrahydropyridine (MPTP) to young (2 months old) and aging (12 months old) C57BL/6 mice (4 X 20 mg/kg i.p. given 12 hr apart) reduced tyrosine hydroxylase (TH)-immunoreactive (IR) fibers in the striatum and reduced dopamine (DA) concentration