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Dissociated release of tetrahydrobiopterin and nitric oxide by lipopolysaccharide from mouse neuroblastoma cells

โœ Scribed by Satoshi Yoshida; Akira Ota; Kazuo Umezawa; Toshiharu Nagatsu

Book ID
116125797
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
387 KB
Volume
212
Category
Article
ISSN
0304-3940

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Nitric oxide (NO) has cytotoxic effects but NO producing neurons are resistant to NO toxicity. These results suggest the presence of self-protecting factors for NO toxicity. Recently, 6R-tetrahydrobiopterin (6R-BH 4 ), a cofactor for NO synthase (NOS), has been reported to degrade NO raising the pos