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Disseminated neuroblastoma in a child with von recklinghausen's disease

✍ Scribed by C. L. Witzleben; Richard A. Landy

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
672 KB
Volume
34
Category
Article
ISSN
0008-543X

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✦ Synopsis

Only two cases of coexisting von Recklinghausen's disease and neuroblastoma have been reported in the English literature, and in both the diagnosis of neurofibromatosis is somewhat tenuous. We report the case of a child with disseminated neuroblastoma who had a previous unequivocal diagnosis of von Recklinghausen's disease, satisfying established criteria. This case adds support to the hypothesis that the origin of neuroblastoma may in a certain number of cases be the result of a germinal mutational abnormality of the neural crest. A description of the pathologic findings in this child with a brief discussion of their implications, and a review of past observations are presented.

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