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Disruption of tumor necrosis factor-α gene diminishes the development of atherosclerosis in ApoE-deficient mice

✍ Scribed by Hirotoshi Ohta; Hisayasu Wada; Tamikazu Niwa; Hirokazu Kirii; Naoki Iwamoto; Hidehiko Fujii; Kuniaki Saito; Kenji Sekikawa; Mitsuru Seishima

Book ID
118420598
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
248 KB
Volume
180
Category
Article
ISSN
0021-9150

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✍ Narci Teoh; Jacqueline Field; Jaim Sutton; Geoffrey Farrell 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 356 KB

Although hepatic ischemia-reperfusion (IR) injury is partially mediated by tumor necrosis factor-alpha (TNF), we recently found that low-dose TNF before IR is hepatoprotective. We examined the seemingly conflicting roles of TNF in mediating liver injury in a partial hepatic IR model using TNF gene k