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Disruption of the ETV6 gene as a consequence of a rare translocation (12;12)(p13;q13) in treatment-induced acute myeloid leukemia after breast cancer

✍ Scribed by Kalliopi N. Manola; Vasileios N. Georgakakos; Dimitris Margaritis; Chryssa Stavropoulou; Christos Panos; Ioannis Kotsianidis; Gabriel E. Pantelias; Constantina Sambani

Book ID
113513242
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
364 KB
Volume
180
Category
Article
ISSN
0165-4608

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A novel cryptic translocation t(12;17)(p13;p12–p13) in a secondary acute myeloid leukemia results in a fusion of the ETV6 gene and the antisense strand of the PER1 gene
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The ETV6 gene is a member of the ETS family of transcription factors and the main target of chromosomal rearrangements affecting chromosome band 12p13. To date, more than 15 fusion partners of ETV6 have been characterized at the molecular level. Most of these fusions encode chimeric proteins with on

Identification of a SRC-like tyrosine ki
Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocation
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## Abstract The SRC family of kinases is rarely mutated in primary human tumors. We report the identification of a SRC‐like tyrosine kinase gene, __FRK__ (Fyn‐related kinase), fused with __ETV6__ in a patient with acute myelogenous leukemia carrying t(6;12)(q21;p13). Both reciprocal fusion transcri