Disruption of positive selection of thymocytes causes autoimmunity
โ Scribed by Rubin, Robert L.; Kretz-Rommel, Anke
- Book ID
- 109827721
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 191 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/73152
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๐ SIMILAR VOLUMES
cells bearing the โฃโค T-cell receptor (TCR) complex recognize antigen in the form of peptide fragments bound to proteins encoded by the host major histocompatibility complex (MHC). Because of the random recombination events regulating generation of the specificity of TCRโฃ and TCRโค proteins, T cells a
The past year has been marked by the application of new technologies to study thymocyte development. These studies have shown that positive selection affects a surprisingly large proportion of thymocytes, and now are beginning to investigate the affinities/avidities of the reactions involved. The le