✦ LIBER ✦

Disposition of the aldose reductase inhibitor AL01576 in rats

✍ Scribed by Y. H. Park; C. B. Wooldridge; J. Mattern; M. L. Stoltz; R. K. Brazzell

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 555 KB
Volume: 77
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600770204

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Disposition of fluvastatin, an inhibitor

Disposition of fluvastatin, an inhibitor of HMG-CoA reductase, in mouse, rat, dog, and monkey

✍ F. L. S. Tse; H. T. Smith; F. H. Ballard; J. Nicoletti 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 579 KB

The physiological disposition offluvastatin, a potent inhibitor of hydroxymethylglutaryl-CoA reductase and thus cholesterol synthesis, has been studied in the mouse, rat, dog, and monkey using 14C-or 3H-labeled drug. Oral doses of fluvastatin were absorbed at a moderate to rapid rate. The extent of

In vivo pharmacokinetics of aldose reduc

In vivo pharmacokinetics of aldose reductase inhibitors: 3-fluoro-3-deoxy-D-glucose NMR studies in rat brains

✍ Ingrid L. Kwee; Tsutomu Nakada 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB

Noninvasive evaluation of effects of an

Noninvasive evaluation of effects of an aldose reductase inhibitor in rat brain by 19F FDG NMR spectroscopy

✍ Tsutomu Nakada; Ingrid L. Kwee 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 361 KB

The inhibitory effects of an aldose reductase inhibitor, sorbinil (Pfizer, NY), on cerebral glucose metabolism were investigated noninvasively in rat brain using 19F nuclear magnetic resonance (NMR) spectroscopy and 2-fluoro-2-deoxy-D-glucose (2-FDG). Sorbinil given orally in the daily recommended d

Absorption and disposition of fluvastati

Absorption and disposition of fluvastatin, an inhibitor of HMG-CoA reductase, in the rabbit

✍ F. L. S. Tse; D. Labbadia 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 464 KB 👁 2 views

The absorption and disposition of fluvastatin have been studied in the female rabbit. In naive rabbits receiving a single oral dose (1 mg kg-I) of [3H]fluvastatin, absorption was rapid and amounted to c. 90 per cent compared with an intravenous reference dose. The drug was subject to considerable fi

ChemInform Abstract: Structure-Based Des

ChemInform Abstract: Structure-Based Design of an Inhibitor Modeled at the Substrate Active Site of Aldose Reductase.

✍ G. RASTELLI; P. VIANELLO; D. BARLOCCO; L. COSTANTINO; A. DEL CORSO; U. MURA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

Reduced nerve blood flow in diabetic rat

Reduced nerve blood flow in diabetic rats: relationship to nitric oxide production and inhibition of aldose reductase

✍ Tomlinson, D.R.; Dewhurst, M.; Stevens, E.J.; Omawari, N.; Carrington, A.L.; Vo, 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB

This study examined links between impaired nitric oxide production in the sciatic endoneurium, nerve blood flow, and polyol pathway flux, to test the hypothesis that reduced nerve blood flow might be compromised by competition for NADPH between aldose reductase and nitric oxide synthase. Sciatic ner