The aim of this study was to predict the disposition of midazolam in individual surgical patients by physiologically based pharmacokinetic (PBPK) modeling and explore the causes of interindividual variability. Tissueยฑplasma partition coefยฎcients (k p ) were scaled from rat to human values by a physi
Disposition of sulfadimethoxine in cattle: Inclusion of protein binding factors in a pharmacokinetic model
โ Scribed by D. W. A. Bourne; M. Bialer; L. W. Dittert; M. Hayashi; G. Rudawsky; G. D. Koritz; R. F. Bevill
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 522 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We have studied the disposition of batanopride and its three major metabolites (the erythro-alcohol, threo-alcohol, and N-desethyl metabolites) in 27 subjects with various degrees of renal function after intravenous infusion of a single dose of 3.6.mg.kg-1 of batanopride over 15 min. The subjects we
Recently, our laboratory reported that intravenous immunoglobulin (IVIG) treatment increased antiplatelet antibody (7E3) clearance in a rat model of immune thrombocytopenic purpura (ITP). However, due to the multifaceted nature of IVIG therapy, the contribution of this increase in antiplatelet antib