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Disposition of enantiomers of sulpiride in humans and rats

✍ Scribed by Ayako Kamizono; Nobuo Inotsume; Shoji Fukushima; Masahiro Nakano; Yoshio Okamoto

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 322 KB
Volume: 14
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510140603

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✦ Synopsis

Abstract

Pharmacokinetics of sulpiride enantiomers after intravenous administration of (±)‐, (+)‐, and (−)‐sulpiride was examined in humans and rats. Pharmacokinetic profiles were similar in (+)‐ and (−)‐enantiomers after intravenous administration of (±)‐sulpiride. Metabolic inversion at a chiral centre was not observed after intravenous administration of each enantiomer in rats.

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