Disposition of venlafaxine enantiomers in rats with hepatic encephalopathy after chronic drug treatment

Influence of chronic hepatic failure on

Influence of chronic hepatic failure on disposition kinetics of valproate excretion through a phase II reaction in rats treated with carbon tetrachloride

✍ Phisit Khemawoot; Chiharu Maruyama; Hirotaka Tsukada; Hiroyo Noda; Junko Ishizak 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

## Abstract The influence of chronic hepatic failure on the disposition kinetics of valproate (VPA) excretion via a phase II reaction was examined in rats treated with carbon tetrachloride (1.0 mg/kg, s.c., 3 times a week) for 2 or 3 months. There was no significant difference in the plasma concent