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Disposition of cyclophosphamide in the rabbit and human cornea

✍ Scribed by Ronald D. Schoenwald; Jeffrey A. Houseman

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 568 KB
Volume: 3
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510030306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Rabbit (dark irides and albino) and human corneas were excised and mounted in a Lucite® chamber in order to determine the permeability of cyclophosphamide‐^14^C and to identify its metabolites. The chromatographic scans obtained from the developed thin‐layer plates showed only one peak for either rabbit or human corneas which corresponded to cyclophosphamide.

By measuring the permeability of cyclophosphamide across the intact cornea, stroma alone, epithelium/stroma, and stroma/endothelium, it was possible to determine the resistance to penetration for each layer. The epithelium was the rate determining barrier, whereas both the stroma and endothelium offered little resistance. The stroma behaves as an inert sieve with drug diffusing through an aqueous media of gel‐like mucopolysaccharide interspersed by a matrix of collagen fibrils.

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