The absorption and disposition of methotrexate (MTX) in the plasma, synovial fluid (SF), skin, and muscle tissue were studied following administration of a topical MTX gel in rabbits and rats. In rabbits, MTX concentrations in the plasma increased steadily toward the peak (5.9 +/- 2.8 ng mL-1) which
Absorption and disposition of ethambutol in rabbits
โ Scribed by M. M. Chen; C. S. Lee; J. H. Perrin
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 348 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
The absorption and disposition of fluvastatin have been studied in the female rabbit. In naive rabbits receiving a single oral dose (1 mg kg-I) of [3H]fluvastatin, absorption was rapid and amounted to c. 90 per cent compared with an intravenous reference dose. The drug was subject to considerable fi
The pharmacologically active compound (33% reduction in rabbit intraocular pressure recovery rate assay) 1-ethyl-6-fluoro-1,2,3,4-tetrahydroquinoline (MC4), which showed ocular hypotensive action and had optimum physicochemical properties, was characterized for its ocular absorption and distribution