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Disposition of 5-aminosalicylic acid, the active metabolite of sulphasalazine, in man

โœ Scribed by C. Fischer; K. Maier; E. Stumpf; U. Gaisberg; U. Klotz

Publisher
Springer
Year
1983
Tongue
English
Weight
414 KB
Volume
25
Category
Article
ISSN
0031-6970

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The metabolic fate of 5-aminosalicylic acid (reported to be the active therapeutic moiety of sulfasalazine) was assessed in fasting rats as a function of dose (25-200 mg/kg) and administration route (oral, intraperitoneal, and intravenous). 5-Aminosalicylic acid is subject to both capacity-limited p

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One gram single dose of Pentasa controlledrelease capsules was administered to 24 healthy volunteers under fasting condition. Mean plasma 5-aminosalicylic acid (5-ASA) and acetyl 5-ASA concentrations peaked at 0.53 gg' m1-1 and 1.33 gg. m1-1 from 3 to 4 hours following dosing, respectively. The half