## Abstract A recirculated perfusion system was used to investigate the metabolism of tramadol, an analgesic agent, in the isolated perfused rat liver. Tramadol was added to the perfusion medium at a concentration of 300โng/ml, and the perfusate samples were collected for 180โmin. The concentration
Disposition kinetics of Saccharomyces boulardii in man and rat
โ Scribed by H. Blehaut; J. Massot; G. W. Elmer; R. H. Levy
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 576 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract One of the most potent carcinogens is 7,12โdimethylbenz(a)anthracene (7,12โDMBA), which is used routinely to conduct studies to evaluate carcinogen inhibitors. Its pharmacokinetics have not been reported in the literature. In view of its significant effects on drug metabolizing enzymes
A 30 mg kg-' intravenous bolus of I4C-amiodarone (19 pCi kg-') was given to male Sprague-Dawley rats pretreated with 0 (vehicle), 25 or 100mgkg-' day-' of amiodarone HCI orally for 37-42 days to determine the effects of dose and duration of administration on the disposition kinetics of amiodarone. S
The disposition of the b-blocking drug talinolol is controlled by P-glycoprotein in man. Because talinolol is marketed as a racemate, we reevaluated the serum-concentration time proยฎles of talinolol of a previously published study with single intravenous (30 mg) and repeated oral talinolol (100 mg f