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Dispacamides, anti-histamine alkaloids from Caribbean Agelas sponges

โœ Scribed by Francesco Cafieri; Ernesto Fattorusso; Alfonso Mangoni; Orazio Taglialatela-Scafati


Book ID
103404671
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
235 KB
Volume
37
Category
Article
ISSN
0040-4039

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Synthesis of dispacamide from the marine
โœ Thomas Lindel; Holger Hoffmann ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 174 KB

The marine natural product dispacamide (1) has been synthesized for the first time starting from 2thiohydantoin (2). A facile one pot conversion of alkylideme thiohydantoins to the corresponding 2-iminoimidazoiones is described employing tert.-butylhydroperoxide (TBHP) in the presence of aqueous amm