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Disease Progression and Pharmacodynamics in Parkinson Disease – Evidence for Functional Protection with Levodopa and Other Treatments

✍ Scribed by Nicholas H. G. Holford; Phylinda L. S. Chan; John G. Nutt; Karl Kieburtz; Ira Shoulson; Parkinson Study Group

Book ID
106423427
Publisher
Springer
Year
2006
Tongue
English
Weight
326 KB
Volume
33
Category
Article
ISSN
1573-8744

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## Abstract We explored the potential effect of catechol‐__O__‐methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from