Discrimination of Diazo Compounds Toward Carbenoids: Copper(I)-Catalyzed Synthesis of Substituted Cyclobutenes
✍ Scribed by José Barluenga; Lorena Riesgo; Luis A. López; Eduardo Rubio; Miguel Tomás
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 278 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0044-8249
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📜 SIMILAR VOLUMES
Ferrocenylamines are excellent catalysts for the enantioselective substitution of unsymmetrical allyl chlorides with dialkylzinc compounds in the presence of a copper(I) salt. For example, in the reaction shown in Equation (1), the product is formed with 87 % ee and a S 2':S 2 ratio of 97:3.
A new catalytic C À C bond-forming reaction has been developed. Catalyzed by cheap and commercially available copper(II) bromide (CuBr 2 ; 10 mol%), the reactions of a-electron-withdrawing group (EWG)-substituted ketene S,S-acetals with aldehydes or ketones in acetonitrile at room temperature gave a