✦ LIBER ✦

Discriminant factor analysis of 31p nmr spectroscopic data in myopathies

✍ Scribed by D. Morvan; P. Jehenson; D. Duboc; A. Syrota

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 546 KB
Volume: 13
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910130205

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Discriminant factor analysis (DFA) enables one to distinguish among diagnostic groups using diagnostic variables. It provides discriminant functions that are linear combinations of the diagnostic variables and that optimally separate diagnostic groups. It was used to enhance the accuracy of ^31^P NMR data in the diagnosis of myopathies. DFA allowed a good separation of normal subjects, congenital neuromuscular disorders with type I fiber predominance, and McArdle's diseases. It elicited an unexpected homogeneity of idiopathic rhabdomyolyses, the metabolic origin of which is unknown, and suggested that the abnormality could involve the mitochondrial oxidative metabolism in some of them. In mitochondrial myopathies, an expected heterogeneity is shown by DFA. It may allow an automatic diagnosis of some myopathies from ^31^P NMR data or guide biochemists by comparing biochemical features of a new patient to those of previously established groups.

📜 SIMILAR VOLUMES

31P NMR spectroscopic investigation of e

31P NMR spectroscopic investigation of exchange processes in two bifunctional aminophosphonates

✍ R. Boetzel; S. Failla; P. Finocchiaro; G. Hägele 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

Variable-temperature 31P NMR spectroscopy was used to extract Arrhenius and Eyring parameters of the hindered rotation about amide bonds in an acylated aminophosphonate. The results permit the differentiation between stepwise or concerted rotation.

31P NMR bayesian spectral analysis of ra

31P NMR bayesian spectral analysis of rat brain in vivo

✍ G. Larry Bretthorst; John J. Kotyk; Joseph J. H. Ackerman 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB 👁 1 views

Bayesian spectrum analysis for parameter estimation is a rigorous statistical (non-Fourier-based) method. Herein the Bayesian quadrature NMR model is introduced and applied to analysis of 3'P NMR time domain data from in vivo rat brain. Immunity to both the brain spectrum "baseline hump" and the pha

Analysis of saturated phosphatidylcholin

Analysis of saturated phosphatidylcholine in amniotic fluid by 31P NMR

✍ J. M. Pearce; J. T. Krone; A. A. Pappas; R. A. Komoroski 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 794 KB

## Abstract A technique using solubilization with sodium cholate to resolve ^31^P NMR resonances of phospholipid molecular species was applied to amniotic fluid samples from 16 subjects. Gestational ages from 25 to 40 weeks were represented, and two subjects were sampled sequentially. Fitting of th

Analysis of phospholipids in human amnio

Analysis of phospholipids in human amniotic fluid by 31P NMR

✍ J. M. Pearce; M. A. Shifman; A. A. Pappas; R. A. Komoroski 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 613 KB

## Abstract A recently described solvent‐reagent system for obtaining narrow linewidths in ^31^P NMR spectra of phospholipid extracts was applied to human amniotic fluid. Resolution of the major components was achieved by manipulating the solvent composition, and assignments were made by spiking sa

Analysis of phospholipid molecular speci

Analysis of phospholipid molecular species in brain by 31P NMR spectroscopy

✍ John M. Pearce; Richard A. Komoroski 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 2 views

Techniques are described for the (31)P NMR analysis of glycerophospholipid (PL) headgroup and molecular species in brain. The (31)P NMR spectrum of PLs from human temporal cortex, solubilized in aqueous Na cholate, typically showed 3 major resonances, assigned to phosphatidylcholine (PC) molecular s

31P Surface-Coil NMR Analysis of Metabol

31P Surface-Coil NMR Analysis of Metabolic Status in KHJJ Tumors

✍ Dorothy A. Adams; Gerald L. Denardo; Sally J. Denardo; Claire B. Conboy; E. Mort 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 525 KB

Noninvasive monitoring of the effects of treatment on cancer tissue is fundamental to the development of rational radioimmunotherapy (RIT) schemes employing radiolabeled monoclonal antibodies or antibody fragments specific for human cancer. Recent advances in nuclear magnetic resonance spectroscopy