✦ LIBER ✦

Discovery of the HCV NS3/4A Protease Inhibitor (1 R ,5 S )- N -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2( S )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( S )-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

✍ Scribed by Prongay, Andrew J.; Guo, Zhuyan; Yao, Nanhua; Pichardo, John; Fischmann, Thierry; Strickland, Corey; Myers, Joseph; Weber, Patricia C.; Beyer, Brian M.; Ingram, Richard; Hong, Zhi; Prosise, Winifred W.; Ramanathan, Lata; Taremi, S. Shane; Yarosh-Tomaine, Taisa; Zhang, Rumin; Senior, Mary; Yang, Rong-Sheng; Malcolm, Bruce; Arasappan, Ashok; Bennett, Frank; Bogen, Stephane L.; Chen, Kevin; Jao, Edwin; Liu, Yi-Tsung; Lovey, Raymond G.; Saksena, Anil K.; Venkatraman, Srikanth; Girijavallabhan, Viyyoor; Njoroge, F. George; Madison, Vincent

Book ID: 126844963
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 495 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm060173k

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery of (1R,5S)-N-[3-Amino-1-(cyclo

Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

✍ Venkatraman, Srikanth; Bogen, Stéphane L.; Arasappan, Ashok; Bennett, Frank; Che 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 312 KB

(2 S ,3 S )-3-Amino-4-(3,3-difluoropyrro

(2 S ,3 S )-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)- N,N -dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5- a ]- pyridin-6-ylphenyl)butanamide: A Selective α-Amino Amide Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

✍ Edmondson, Scott D.; Mastracchio, Anthony; Mathvink, Robert J.; He, Jiafang; Har 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 355 KB

Structural studies of intermediates in a

Structural studies of intermediates in antibiotic synthesis. I. The structures of penicillin sulfoxide rearrangement products: 2,3,5,6-tetrahydro-5-hydroxymethyl-6,6-dimethyl-1,3-dioxo-8-[(phenylacetyl)amino]-1H-imidazo[5,1-c][1,4]thiazine (I) , C17H19N3O4S, and 2,3,5,6-tetrahydro-6,6-dimethyl-1,3-dioxo-8-[(phenylacetyl)amino]-1H-imidazo[5,1-c][1,4]thiazine-5-carboxylic acid (II), C17H17N3O5S

✍ Haran, T. E. ;Nudelman, A. ;Shakked, Z. 📂 Article 📅 1983 🏛 International Union of Crystallography 🌐 English ⚖ 695 KB

Molar Enthalpy of Crystallization of (2

Molar Enthalpy of Crystallization of (2 S ,5 R ,6 R )-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid in Aqueous Sodium Sulfate and Ammonium Sulfate Solutions †

✍ Su, Min; Wang, Jingkang 📂 Article 📅 2010 🏛 American Chemical Society 🌐 English ⚖ 98 KB

Piperazine-Based CCR5 Antagonists as HIV

Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1( R )-4-(trifluoromethyl)phenyl}ethyl-3( S )-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a Potent, Highly Selective, and Orally Bioavailable CCR5 Antagonist

✍ Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 78 KB