𝔖 Bobbio Scriptorium
✦   LIBER   ✦

(2 S ,3 S )-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)- N,N -dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5- a ]- pyridin-6-ylphenyl)butanamide: A Selective α-Amino Amide Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

✍ Scribed by Edmondson, Scott D.; Mastracchio, Anthony; Mathvink, Robert J.; He, Jiafang; Harper, Bart; Park, You-Jung; Beconi, Maria; Di Salvo, Jerry; Eiermann, George J.; He, Huaibing; Leiting, Barbara; Leone, Joseph F.; Levorse, Dorothy A.; Lyons, Kathryn; Patel, Reshma A.; Patel, Sangita B.; Petrov, Aleksandr; Scapin, Giovanna; Shang, Jackie; Roy, Ranabir Sinha; Smith, Aaron; Wu, Joseph K.; Xu, Shiyao; Zhu, Bing; Thornberry, Nancy A.; Weber, Ann E.


Book ID
118268012
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
355 KB
Volume
49
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Discovery of ((4 R ,5 S )-5-Amino-4-(2,4
Discovery of N-benzyl-2-[(4S)-4-(1H-indo
✍ Richard L. Elliott; Kimberly O. Cameron; Janice E. Chin; Jeremy A. Bartlett; Ele 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 598 KB

We describe the design, synthesis, and structure-activity relationships of triazolobenzodiazepinone CCK1 receptor agonists. Analogs in this series demonstrate potent agonist activity as measured by in vitro and in vivo assays for CCK1 agonism. Our efforts resulted in the identification of compound 4