Discovery of novel class 1 phosphatidyli
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Fabrizio Giordanetto; Bengt Kull; Anita Dellsén
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Article
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2011
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Elsevier Science
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English
⚖ 1002 KB
The discovery of ligand efficient and lipophilicity efficient fragment inhibitors of class 1 phosphatidylinositide 3-kinases (PI3K) is reported. A fragment version of the AstraZeneca compound bank was docked to a homology model of the PI3K p110β isoform. Interaction-based scoring of the predicted bi