✦ LIBER ✦

Discovery of S -(2-Guanidylethyl)-isothiourea (VUF 8430) as a Potent Nonimidazole Histamine H 4 Receptor Agonist

✍ Scribed by Lim, Herman D.; Smits, Rogier A.; Bakker, Remko A.; van Dam, Cindy M. E.; de Esch, Iwan J. P.; Leurs, Rob

Book ID: 120368737
Publisher: American Chemical Society
Year: 2006
Tongue: English
Weight: 44 KB
Volume: 49
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm060880d

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery of potent and selective histam

Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold

✍ H.G.F. Richter; C. Freichel; J. Huwyler; T. Nakagawa; M. Nettekoven; J.-M. Planc 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 453 KB

A novel series of potent histamine H(3) receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold has been discovered. Several compounds display high selectivity over other histamine receptor subtypes and have favorable physicochemical properties, low potential for CY

Discovery and Characterization of 6-{4-[

Discovery and Characterization of 6-{4-[3-( R )-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2 H -pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H 3 Receptor Inverse Agonist

✍ Hudkins, Robert L.; Raddatz, Rita; Tao, Ming; Mathiasen, Joanne R.; Aimone, Lisa 📂 Article 📅 2011 🏛 American Chemical Society 🌐 English ⚖ 1007 KB

Discovery of (1R,6S)-5-[4-(1-cyclobutyl-

Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): Histamine H3 receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity

✍ Hudkins, Robert L.; Josef, Kurt A.; Becknell, Nadine C.; Aimone, Lisa D.; Lyons, 📂 Article 📅 2014 🏛 Elsevier Science 🌐 English ⚖ 582 KB

Characterization of the 1 H -Cyclopentap

Characterization of the 1 H -Cyclopentapyrimidine-2,4(1 H ,3 H )-dione Derivative (S)-CPW399 as a Novel, Potent, and Subtype-Selective AMPA Receptor Full Agonist with Partial Desensitization Properties

✍ Campiani, Giuseppe; Morelli, Elena; Nacci, Vito; Fattorusso, Caterina; Ramunno, 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 134 KB

Discovery of 4-[3-( trans -3-Dimethylami

Discovery of 4-[3-( trans -3-Dimethylaminocyclobutyl)-1 H -indol-5-ylmethyl]- (4 S )-oxazolidin-2-one (4991W93), a 5HT 1B/1D Receptor Partial Agonist and a Potent Inhibitor of Electrically Induced Plasma Extravasation

✍ Jandu, Karamjit Singh; Barrett, Vikki; Brockwell, Michael; Cambridge, David; Far 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 217 KB

Synthesis of (1S,3aS)-8-(2,3,3a,4,5,6-he

Synthesis of (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one, a potent and selective orphanin FQ (OFQ) receptor agonist with anxiolytic-like properties

✍ Jürgen Wichmann; Geo Adam; Stephan Röver; Michael Hennig; Michelangelo Scalone; 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 363 KB