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Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists

โœ Scribed by Gillespie, Paul; Goodnow, Robert A.; Saha, Goutam; Bose, Gopal; Moulik, Kakali; Zwingelstein, Catherine; Myers, Michael; Conde-Knape, Karin; Pietranico-Cole, Sherrie; So, Sung-Sau


Book ID
121490740
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
687 KB
Volume
24
Category
Article
ISSN
0960-894X

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๐Ÿ“œ SIMILAR VOLUMES


A convenient synthesis of pyrazolo[3,4-d
โœ M. El Haddad; M. Soukri; S. Lazar; A. Bennamara; G. Guillaumet; M. Akssira ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 470 KB

## Abstract Pyrazoloโ€[3,4โ€__d__]pyrimidineโ€4,6โ€diones **5** and pyrazolo[4,3โ€__d__]pyrimidineโ€5,7โ€diones **7** were synthesized by Curtius rearrangement of pyrazolic monoโ€esters **2** and **3** followed by heteroโ€cyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.