✦ LIBER ✦

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH 2 -Terminal Kinase Inhibitors

✍ Scribed by Zhao, Hongyu; Serby, Michael D.; Xin, Zhili; Szczepankiewicz, Bruce G.; Liu, Mei; Kosogof, Christi; Liu, Bo; Nelson, Lissa T. J.; Johnson, Eric F.; Wang, Sanyi; Pederson, Terry; Gum, Rebecca J.; Clampit, Jill E.; Haasch, Deanna L.; Abad-Zapatero, Cele; Fry, Elizabeth H.; Rondinone, Cristina; Trevillyan, James M.; Sham, Hing L.; Liu, Gang

Book ID: 125942909
Publisher: American Chemical Society
Year: 2006
Tongue: English
Weight: 113 KB
Volume: 49
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm060465l

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery of Substituted 4-(Pyrazol-4-yl

Discovery of Substituted 4-(Pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as Potent and Highly Selective Rho Kinase (ROCK-II) Inhibitors

✍ Feng, Yangbo; Yin, Yan; Weiser, Amiee; Griffin, Evelyn; Cameron, Michael D.; Lin 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 427 KB

The Discovery and Optimization of a Nove

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

✍ Lewis, Richard T.; Bode, Christiane M.; Choquette, Deborah M.; Potashman, Michel 📂 Article 📅 2012 🏛 American Chemical Society 🌐 English ⚖ 594 KB

Discovery of a Potent, Selective, and Or

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)- N -(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazole-4-carboxamide (AMG 458)

✍ Liu, Longbin; Siegmund, Aaron; Xi, Ning; Kaplan-Lefko, Paula; Rex, Karen; Chen, 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 191 KB

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1 H -pyrazolo[3,4- c ]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

✍ Pinto, Donald J. P.; Orwat, Michael J.; Koch, Stephanie; Rossi, Karen A.; Alexan 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 666 KB

Design and Synthesis of the First Genera

Design and Synthesis of the First Generation of Novel Potent, Selective, and in Vivo Active (Benzothiazol-2-yl)acetonitrile Inhibitors of the c-Jun N-Terminal Kinase

✍ Gaillard, Pascale; Jeanclaude-Etter, Isabelle; Ardissone, Vittoria; Arkinstall, 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 209 KB

Discovery of 1-[3-(Aminomethyl)phenyl]-N

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa1

✍ Pinto, Donald J. P.; Orwat, Michael J.; Wang, Shuaige; Fevig, John M.; Quan, Mim 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 320 KB