✦ LIBER ✦

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models

✍ Scribed by Albaugh, Pam; Fan, Yi; Mi, Yuan; Sun, Fangxian; Adrian, Francisco; Li, Nanxin; Jia, Yong; Sarkisova, Yelena; Kreusch, Andreas; Hood, Tami; Lu, Min; Liu, Guoxun; Huang, Shenlin; Liu, Zuosheng; Loren, Jon; Tuntland, Tove; Karanewsky, Donald S.; Seidel, H. Martin; Molteni, Valentina

Book ID: 118003553
Publisher: American Chemical Society
Year: 2012
Tongue: English
Weight: 829 KB
Volume: 3
Category: Article
ISSN: 1948-5875
DOI: 10.1021/ml200261d

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

✍ Sampath-Kumar Anandan; Heather Kay Webb; Dawn Chen; Yi-Xin (Jim) Wang; Basker R. 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 339 KB

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea 14a (AR9281), a potent and selective soluble epoxide hydrolase inhibitor, was recently tested in a phase 2a clinical setting for its effectiveness in reducing blood pressure and improving insulin resistance in pre-diabetic patients. In a mouse model

ChemInform Abstract: 1-(1-Acetyl-piperid

ChemInform Abstract: 1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a Potent, Selective, and Orally Available Soluble Epoxide Hydrolase Inhibitor with Efficacy in Rodent Models of Hypertension and Dysglycemia.

✍ Sampath-Kumar Anandan; et al. et al. 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 19 KB

## Abstract The synthesis of the clinical candidate (I) and its analogues is achieved via a library approach allowing the facile preparation of various left hand side and right hand side combinations around the piperidinyl urea nucleus.