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Discovery of dopamine D4 receptor antagonists with planar chirality

✍ Scribed by Sanna, Fabrizio; Ortner, Birgit; Hübner, Harald; Löber, Stefan; Tschammer, Nuska; Gmeiner, Peter

Book ID
120059886
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
473 KB
Volume
21
Category
Article
ISSN
0968-0896

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The identification of a novel dopamine receptor subtype, referred to as the D4 receptor, which binds the atypical antipsychotic drug clozapine with high potency, has led to the initiation of a drug discovery program that aims to find novel inhibitors of this receptor subtype. A selective screening s