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Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6

✍ Scribed by Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.


Book ID
118739898
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
433 KB
Volume
48
Category
Article
ISSN
0022-2623

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Structure-guided discovery of cyclin-dep
✍ Thierry O. Fischmann; Alan Hruza; JosΓ© S. Duca; Lata Ramanathan; Todd Mayhood; W πŸ“‚ Article πŸ“… 2008 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 380 KB πŸ‘ 1 views

## Abstract CDK2 inhibitors containing the related bicyclic heterocycles pyrazolopyrimidines and imidazopyrazines were discovered through high‐throughput screening. Crystal structures of inhibitors with these bicyclic cores and two more related ones show that all but one have a common binding mode