Discovery and design of novel inhibitors
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J. Hayden; J. Pires; S. Roy; M. Hamilton; G. J. Moore
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Article
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2003
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John Wiley and Sons
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English
β 247 KB
Intoxication by the zinc protease botulinus neurotoxin A (BoNT-A) results from cleavage of a single Q-R bond in the neuronal protein SNAP-25, which disables the docking mechanism required for neurotransmitter release. In the present study, potential inhibitors of BoNT-A were assessed from their effe