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Discovery and SAR of a Novel Selective and Orally Bioavailable Nonpeptide Classical Competitive Inhibitor Class of Protein-Tyrosine Phosphatase 1B

✍ Scribed by Andersen, Henrik Sune; Olsen, Ole H.; Iversen, Lars F.; Sørensen, Anette L. P.; Mortensen, Steen B.; Christensen, Michael S.; Branner, Sven; Hansen, Thomas K.; Lau, Jesper F.; Jeppesen, Lone; Moran, Edmond J.; Su, Jing; Bakir, Farid; Judge, Luke; Shahbaz, Manou; Collins, Tassie; Vo, Todd; Newman, Michael J.; Ripka, William C.; Møller, Niels Peter H.


Book ID
120450918
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
347 KB
Volume
45
Category
Article
ISSN
0022-2623

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A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.