A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.
✦ LIBER ✦
Discovery and SAR of a Novel Selective and Orally Bioavailable Nonpeptide Classical Competitive Inhibitor Class of Protein-Tyrosine Phosphatase 1B
✍ Scribed by Andersen, Henrik Sune; Olsen, Ole H.; Iversen, Lars F.; Sørensen, Anette L. P.; Mortensen, Steen B.; Christensen, Michael S.; Branner, Sven; Hansen, Thomas K.; Lau, Jesper F.; Jeppesen, Lone; Moran, Edmond J.; Su, Jing; Bakir, Farid; Judge, Luke; Shahbaz, Manou; Collins, Tassie; Vo, Todd; Newman, Michael J.; Ripka, William C.; Møller, Niels Peter H.
- Book ID
- 120450918
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 347 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-2623
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