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Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B

✍ Scribed by Izidor Sosič; Bojana Mirković; Samo Turk; Bogdan Štefane; Janko Kos; Stanislav Gobec


Book ID
113583089
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
849 KB
Volume
46
Category
Article
ISSN
0223-5234

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A One-Pot Biginelli Synthesis of 6-Unsub
✍ Elham Sayed Darwish; Ismail Abdelshafy Abdelhamid; Miead Adel Nasra; Fathy Moham 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 German ⚖ 147 KB

## Abstract The three‐component __Biginelli__‐like cyclocondensation reaction of enamines **1**, urea, and aldehydes in dioxane/acetic acid efficiently afforded the corresponding 6‐unsubstituted 3,4‐dihydropyrimidin‐2(1__H__)‐ones **2** in good yields (__Scheme 1, Table__). The corresponding reacti