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A One-Pot Biginelli Synthesis of 6-Unsubstituted 5-Aroylpyrimidin-2(1H)-ones and 6-Acetyl-1,2,4-triazin-3(2H)-ones

✍ Scribed by Elham Sayed Darwish; Ismail Abdelshafy Abdelhamid; Miead Adel Nasra; Fathy Mohamed Abdel-Gallil; Daisy Hanna Fleita

Publisher: John Wiley and Sons
Year: 2010
Tongue: German
Weight: 147 KB
Volume: 93
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200900355

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✦ Synopsis

Abstract

The three‐component Biginelli‐like cyclocondensation reaction of enamines 1, urea, and aldehydes in dioxane/acetic acid efficiently afforded the corresponding 6‐unsubstituted 3,4‐dihydropyrimidin‐2(1__H__)‐ones 2 in good yields (Scheme 1, Table). The corresponding reaction of azaenamine (=hydrazone) 7 with benzaldehyde and urea afforded 6‐acetyl‐1,2,4‐triazin‐3(2__H__)‐ones in good yields (Scheme 3).

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