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Discovery and Development of Novel HDAC Inhibitors for Huntington’s Disease

✍ Scribed by H. Patzke; R. Chesworth; Z. Li; G. Rahil; J. Wang; J. Smith; F.L. Huet; G. Shapiro; S. Leit; P. Beaulieu; F. Raeppel; M. Fournel; H. Sainte-Croix; S.J. Nolan; F.P. Albayya; A. Barbier; J. Besterman; M.K. Ahlijanian; R. Deziel


Book ID
116800755
Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
44 KB
Volume
5
Category
Article
ISSN
1933-7213

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## Abstract Stereotaxic injection of kainic acid into rat striatum produces neuronal degeneration and neurochemical alterations resembling Huntington's disease (HD). Since correction of the deficiency in γ‐aminobutyric acid (GABA) in HD may be of therapeutic value, the efficacy of drugs that inhibi