Discovery and Development of 11C-Lu AE92686 as a Radioligand for PET Imaging of Phosphodiesterase10A in the Brain
✍ Scribed by Kehler, Jan (author);Kilburn, John Paul (author);Estrada, Sergio (author);Christensen, Søren Rahn (author);Wall, Anders (author);Thibblin, Alf (author);Lubberink, Mark (author);Bundgaard, Christoffer (author);Brennum, Lise Tøttrup (author);Steiniger-Brach, Björn (author);Christoffersen, Claus Tornby (author);Timmermann, Stine (author);Kreilgaard, Mads (author);Antoni, Gunnar (author);Bang-Andersen, Benny (author);Nielsen, Jacob (author)
- Book ID
- 126297930
- Publisher
- Society of Nuclear Medicine Inc.
- Year
- 2014
- Tongue
- English
- Weight
- 898 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0161-5505
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The peripheral benzodiazepine receptor (PBR) is expressed by microglial cells in many neuropathologies involving neuroinflammation. PK11195, the reference compound for PBR, is used for positron emission tomography (PET) imaging but has a limited capacity to quantify PBR expression. Here
## Abstract __Introduction:__ (__R__)‐3‐(2‐(methylthio)phenoxy)‐__N__‐methyl‐3‐phenylpropan‐1‐amine [(__R__)–thionisoxetine; **1**] is a potent inhibitor of the norepinephrine transporter (NET). We aimed to label **1** with carbon‐11 (__t__~1/2~ = 20.4 min) for evaluation as a radioligand for imagi