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Discovery and biological characterization of capromorelin analogues with extended half-lives

✍ Scribed by Philip A. Carpino; Bruce A. Lefker; Steven M. Toler; Lydia C. Pan; John R. Hadcock; Marianne C. Murray; Ewell R. Cook; Joseph N. DiBrino; Shari L. DeNinno; Kristin L. Chidsey-Frink; William A. Hada; John Inthavongsay; Sharon K. Lewis; F.Michael Mangano; Michelle A. Mullins; David F. Nickerson; Oicheng Ng; Christine M. Pirie; John A. Ragan; Colin R. Rose; David A. Tess; Ann S. Wright; Li Yu; Michael P. Zawistoski; John C. Pettersen; Paul A. DaSilva-Jardine; Theresa C. Wilson; David D. Thompson

Book ID
108477326
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
130 KB
Volume
12
Category
Article
ISSN
0960-894X

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✍ Marcos A. Fázio; Laurence Jouvensal; Françoise Vovelle; Philippe Bulet; M. Terês 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 508 KB

## Abstract Gomesin (__Gm__) is a potent antimicrobial peptide isolated from the spider Acanthoscurria gomesiana. The two disulfide bridges Cys^2,15^ and Cys^6,11^ facilitate the folding of the molecule in a β‐hairpin structure, conferring on the peptide a high stability in human plasma. We report